研究方向

1. 新型污染物的高通量检测与识别

2. 新型污染物的人体暴露特征与健康效应

3. 新型污染物的毒性效应及分子机制

4. 基于毒性规律指导化学品绿色替代与合成

研究领域包括环境分析、环境健康与毒理学，鼓励多学科交叉研究，欢迎具有环境科学、分子生物学、组学与生物信息学、分析化学等专业背景的同学参加本科生科研，攻读硕士、博士学位。

个人简历

1996年－1999年 南京大学环境学院，获博士学位

1999年－2000年 同济大学57365线路检测中心，博士后

2000年－2001年，美国德克萨斯州立大学加尔韦斯顿医学分校，博士后

2001年－2005年，美国康奈尔大学医学院，生物化学系，博士后

2005年－2020年，中国科学院动物研究所，中国科学院动物生态与保护生物学重点实验室，主任，研究员

2020年－至今，57365线路检测中心，特聘教授

    国家杰出青年基金获得者（2010年），中科院"Bairen计划"入选者（2005年，终期评估优秀），美国化学会（ACS）Chemical Research in Toxicology杂志副主编（2018年1月-至今）。中国毒理学会环境与生态毒理学专业委员会 常务委员（第一~三届）；中国环境学会环境风险专业委员会 委员（2012年1月-至今）；中国环境科学学会持久性有机污染物专业委员会 委员（2012年1月-至今）；中国毒理学会计算毒理专业委员会委员（第一届-至今）；中华预防医学会环境卫生分会常务委员（第八届）。中国科学院城市环境研究所城市环境健康重点实验室 学术委员会委员（2013年1月-至今）；安徽省湿地生态保护与修复重点实验室 学术委员会委员（2018年-至今）。

    先后主持或参加国家自然科学杰出青年基金项目、重点项目、重大国际合作项目、面上项目、973项目和重点研发计划的课题、中科院知识创新工程重要方向性项目、中科院战略先导B项目的课题等19项。2004年以来在Cell, Environmental Health Perspectives, Molecular Cellular Proteomics, Environmental Sciences & Technology等重要SCI刊物发表论文127篇（其中第一作者或通讯作者99篇），他引3471次，H因子35。培养的研究生多人次先后获中国科学院优秀博士论文、中国科学院院长优秀奖、朱李月华奖学金、地奥奖学金（一等和二等）、5人次获国家奖学金（博士研究生4人和硕士研究生1人）。

科研成果

代表性科研项目（10项）

1. 国家自然科学基金委重点项目（21737004），基于系统性毒性研究指导全氟烷基化合物替代品设计与绿色合成，2018/01-2022/12，300万，主持

2. 国家重点研发计划生殖专项，课题二（2018YFC1004202），男性不育的环境-基因交互作用研究，2018/12-2021/12，188万（987万），参加

3 国家自然科学基金委面上项目（21876173），全氟烷基化合物替代品影响斑马鱼鱼鳔发育的分子机制研究，2019/01-2022/12，66万，主持

4. 国家重点研发计划食品专项，课题五（2017YFC1600205），食品中典型持久性有机污染物健康危害与毒性机制，2017/01-2021/12，300万，课题负责人

5. 国家自然科学基金委面上项目（21377128），全氟类化合物与人类肝脏型脂肪酸结合蛋白的相互作用及毒性机制研究，2014/01-2017/12，88万，主持

6. 国家自然科学基金国际(地区)合作与交流项目（31320103915），野生动物体内全氟烷基化合物的来源、存在状态及毒性机制研究，2014/1-2018/12，274万，主持

7. 中科院先导B专项，项目四课题二子课题二（XDB14040202），典型污染物引发机体糖和脂肪代谢紊乱的机制，2014/07-2019/06，421万，子课题负责人

8. 国家重点基础研究发展计划（973计划），课题四（2013CB945204），血脂紊乱影响精子发生的生物标记物的鉴定和临床干预，2013/01-2017/08，556万，课题负责人

9. 国家自然科学基金委杰出青年基金项目（31025006），持久性有机污染物的生态毒理机制，2011/01-2014/12，200万元，主持

10. 国家自然科学基金委重点项目（20837004），典型全氟有机污染物的水环境过程及生态毒理机制研究，2009/01-2012/12，200万元，主持

近五年代表性论文（30篇）

(1) Yao Jingzhi, Pan Yitao, Sheng Nan, Su Zhaoben, Guo Yong, Wang Jianshe, Dai, Jiayin^(*), Novel perfluoroalkyl ether carboxylic acids (PFECAs) and sulfonic acids (PFESAs): Occurrence and association with serum biochemical parameters in residents living near a fluorochemical plant in China, Environmental Science & Technology, 2020, 54 (21): 13389-13398

(2) Wang Jinghua, Pan Yitao, Wei Xiaofei, Dai, Jiayin^(*), Temporal Trends in Prenatal Exposure (1998-2018) to Emerging and Legacy Per- and Polyfluoroalkyl Substances (PFASs) in Cord Plasma from the Beijing Cord Blood Bank, China, Environmental Science & Technology, 2020, 54 (20): 12850-12859

(3) Cui Qianqian, Pan Yitao, Wang Jinghua, Liu Hongxiu, Yao Bing, Dai, Jiayin^(*), Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones, Environmental Pollution, 2020, 266 (2): 115330

(4) Liu Hongxiu^(#), Pan Yitao^(#), Jin Shuna; Sun Xiaojie, Jiang Yangqian, Wang Yuyan, Ghassabian Akhgar, Li Yuanyuan, Xia Wei, Cui Qianqian, Zhang Bin, Zhou Aifen, Dai Jiyin^(*), Xu Shunqing^(*). Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China. Journal of hazardous materials, 2020, 124378

(5) Liu Hongxiu^(#), Pan Yitao^(#), Jin Shuna, Li Yuanyuan, Zhao Liuqing, Sun Xiaojie, Cui Qianqian, Zhang bin, Zheng Tongzhang, Xia Wei, Zhou Aifen, Campana Anna Maria, Dai Jiyin^(*), Xu Shunqing^(*). Associations of per-/polyfluoroalkyl substances with glucocorticoids and progestogens in newborns, Environment International, 2020, 140: 105636

(6) Pan, Yitao, Wang, Jinghua, Yeung, L. W. Y., Wei, Si, Dai, Jiayin^(*), Analysis of emerging per- and polyfluoroalkyl substances: Progress and current issues, Trends in Analytical Chemistry, 2020, 124: 115481

(7) Wang, Jinxing^(#), Shi Guohui^(#), Yao Jingzhi, Sheng Nan, Cui, Ruina, Su Zhaoben, Guo, Yong, Dai, Jiayin^(*), Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption, Environment International, 2020, 134: 105317

(8) Pan, Yitao, Cui, Qianqian, Wang, Jinghua, Sheng Nan, Jing, Jun, Yao, Bing^(*), Dai, Jiayin^(*), Profiles of Emerging and Legacy Per-/Polyfluoroalkyl Substances in Matched Serum and Semen Samples: New Implications for Human Semen Quality, Environmental Health Perspectives, 2019, 127 (12): 127005

(9) Cui, Qianqian^(#), Shi, Fanglei^(#), Pan, Yitao, Zhang, Hongxia, Dai, Jiayin^(*), Per- and polyfluoroalkyl substances (PFASs) in the blood of two colobine monkey species from China: Occurrence and exposure pathways, Science of the Total Environment, 2019, 674: 524-531

(10) Guo, Hua, Wang, Jinghua, Yao, Jingzhi, Sun, Sujie, Sheng, Nan, Zhang, Xiaowen, Guo, Xuejiang, Guo, Yong, Sun, Yan, Dai, Jiayin^(*), Comparative hepatotoxicity of novel PFOA alternatives (perfluoropolyether carboxylic acids) on Male Mice, Environmental Science & Technology, 2019, 53 (7): 3929-3937

(11) Shi, Guohui, Cui, Qianqian, Wang, Jinxing, Guo, Hua, Pan, Yitao, Sheng, Nan, Guo, Yong, Dai, Jiayin^(*), Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring, Environmental Pollution, 2019, 249: 550-559

(12) Shi, Guohui, Wang, Jinxing, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin^(*), Parental exposure to 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) induced transgenerational thyroid hormone disruption in zebrafish, Science of the Total Environment, 2019, 665: 855-863

(13) Sun, Sujie, Guo, Hua, Wang, Jianshe^(*), Dai, Jiayin, Hepatotoxicity of perfluorooctanoic acid and two emerging alternatives based on a 3D spheroid model, Environmental Pollution, 2019, 246: 955-962

(14) Cui, Ruina, Li, Chenyang, Wang, Jianshe^(*), Dai, Jiayin, Induction of hepatic miR-34a by perfluorooctanoic acid regulates metabolism-related genes in mice, Environmental Pollution, 2019, 244: 270-278

(15) Wang, Jinghua^(#), Pan, Yitao^(#), Cui, Qianqian, Yao, Bing, Wang, Jianshe^(*), Dai, Jiayin, Penetration of PFASs across the Blood Cerebrospinal Fluid Barrier and Its Determinants in Humans, Environmental Science & Technology, 2018, 52 (22): 13553-13561

(16) Sun, Sujie, Wang, Jianshe^(*), Lu, Yin, Dai, Jiayin, Corticosteroid-Binding Globulin, Induced in Testicular Leydig Cells by Perfluorooctanoic Acid, Promotes Steroid Hormone Synthesis, Archives of Toxicology, 2018, 92 (6): 2013-2025

(17) Zhou, Xiujuan, Wang, Jianshe^(*), Sheng, Nan, Cui, Ruina, Deng, Yiqun, Dai, Jiayin, Subchronic Reproductive Effects of 6:2 Chlorinated Polyfluorinated Ether Sulfonate (6:2 Cl-Pfaes), an Alternative to PFOS, on Adult Male Mice, Journal of Hazardous Materials, 2018, 358: 256-264

(18) Zhang, Hongxia, Zhou, Xiujuan, Sheng, Nan, Cui, Ruina, Cui, Qianqian, Guo, Hua, Guo, Yong, Sun, Yan, Dai, Jiayin*, Subchronic hepatotoxicity effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), a novel perfluorooctanesulfonate (PFOS) alternative, on adult male mice, Environmental Science & Technology, 2018, 52 (21): 12809-12818

(19) Shi, Guohui, Guo, Hua, Sheng, Nan, Cui, Qianqian, Pan, Yitao, Wang, Jinxing, Guo, Yong, Dai, Jiayin*, Two-generational reproductive toxicity assessment of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B, a novel alternative to perfluorooctane sulfonate) in Zebrafish, Environmental Pollution, 2018, 243: 1517-1527

(20) Cui, Qianqian, Pan, Yitao, Zhang, Hongxia, Sheng, Nan, Dai, Jiayin^(*), Elevated concentrations of perfluorohexanesulfonate and other per and polyfluoroalkyl substances in Baiyangdian Lake (China): source characterization and exposure assessment, Environmental Pollution, 2018, 241: 684-691

(21) Cui, Qianqian^(#), Pan, Yitao^(#), Zhang, Hongxia, Sheng, Nan, Wang, Jianshe, Guo, Yong, Dai, Jiayin^(*), Occurrence and tissue distribution of novel ferfluoroether carboxylic and sulfonic acids and legacy per/polyfluoroalkyl substances in Black-Spotted Frog (Pelophylax Nigromaculatus), Environmental Science & Technology, 2018, 52 (3): 982-990 （ESI数据库（highly cited papers）收录）

(22) Pan, Yitao^(#), Zhang, Hongxia^(#), Cui, Qianqian, Sheng, Nan, Yeung, Leo W. Y., Sun, Yan, Guo, Yong, Dai, Jiayin^(*), Worldwide distribution of novel perfluoroether carboxylic and sulfonic acids in surface water, Environmental Science & Technology, 2018, 52 (14): 7621-7629 （ESI数据库（highly cited papers）收录）

(23) Sheng, Nan, Cui, Ruina, Wang, Jinghua, Guo, Yong, Wang, Jianshe, Dai, Jiayin^(*), Cytotoxicity of novel fluorinated alternatives to long-chain perfluoroalkyl substances to human liver cell Line and their binding capacity to human liver fatty acid binding protein, Archives of Toxicology, 2018, 92 (1): 359-369 （ESI数据库（highly cited papers）收录）

(24) Sheng, Nan, Pan, Yitao, Guo, Yong, Sun, Yan, Dai, Jiayin^(*), Hepatotoxic effects of hexafluoropropylene oxide trimer acid (HFPO-TA), a novel perfluorooctanoic acid (PFOA) alternative, on mice, Environmental Science & Technology, 2018, 52 (14): 8005-8015

(25) Shi, Guohui, Xie, Yu, Guo, Yong, Dai, Jiayin^(*), 6:2 Fluorotelomer sulfonamide alkylbetaine (6:2 ftab), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in Zebrafish embryos, Aquatic Toxicology, 2018, 195: 24-32

(26) Pan Yitao, Zhang Hongxia, Cui Qianqian, Sheng Nan, Yeung Leo W. Y., Guo Yong, Sun Yan, Dai, Jiayin^(*).First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: an emerging concern, Environmental Science & Technology, 2017, 51(17): 9553-9560

(27) Shi Guohui, Cui Qianqian, Pan Yitao, Sheng Nan, Guo Yong, Dai, Jiayin^(*).6:2 fluorotelomer carboxylic acid (6:2 FTCA) exposure induces developmental toxicity and inhibits the formation of erythrocytes during zebrafish embryogenesis, Aquatic Toxicology, 2017, 190: 53-61

(28) Shi, Guohui, Cui, Qianqian, Pan, Yitao, Sheng, Nan, Sun, Sujie, Guo, Yong, Dai, Jiayin^(*), 6:2 Chlorinated polyfluorinated ether sulfonate, a PFOS alternative, induces embryotoxicity and disrupts cardiac development in zebrafish embryos, Aquatic Toxicology, 2017, 185: 67-75 （ESI数据库（highly cited papers）收录）

(29) Yan, Shengmin, Zhang, Hongxia, Guo, Xuejiang, Wang, Jianshe, Dai, Jiayin^(*), High perfluorooctanoic acid exposure induces autophagy blockage and disturbs intracellular vesicle fusion in the liver, Archives of Toxicology, 2017, 91 (1): 247-258

(30) Pan, Yitao^(#), Zhu, Yingshuang^(#), Zheng, Tongzhang, Cui, Qianqian, Buka, Stephen L, Zhang, Bin, Guo, Yong, Xia, Wei, Yeung, Leo W Y, Li, Yuanyuan, Zhou, Aifen, Qiu, Lin, Liu, Hongxiu, Jiang, Minmin, Wu, Chuansha, Xu, Shunqing^(*), Dai, Jiayin^(*), Novel chlorinated polyfluorinated ether sulfonates and legacy per-/polyfluoroalkyl substances: placental transfer and relationship with serum albumin and glomerular filtration rate, Environmental Science & Technology, 2017, 51 (1): 634-644 （ESI数据库（highly cited papers）收录）

荣获奖励

中国科学院优秀导师奖（2019年度）；

中国科学院朱李月华优秀教师奖（2012年度）；